Sulforaphane Potentiates Anticancer Effects of Doxorubicin and Cisplatin and Mitigates Their Toxic Effects.
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ABSTRACT:
SUBMITTER: Calcabrini C
PROVIDER: S-EPMC7207042 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Sulforaphane Potentiates Anticancer Effects of Doxorubicin and Cisplatin and Mitigates Their Toxic Effects.
Calcabrini Cinzia C Maffei Francesca F Turrini Eleonora E Fimognari Carmela C
Frontiers in pharmacology 20200501
The success of cancer therapy is often compromised by the narrow therapeutic index of many anticancer drugs and the occurrence of drug resistance. The association of anticancer therapies with natural compounds is an emerging strategy to improve the pharmaco-toxicological profile of cancer chemotherapy. Sulforaphane, a phytochemical found in cruciferous vegetables, targets multiple pathways involved in cancer development, as recorded in different cancers such as breast, brain, blood, colon, lung, ...[more]
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