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Using free association networks to extract characteristic patterns of affect dynamics.

ABSTRACT: The dynamics of human affect in day-to-day life are an intrinsic part of human behaviour. Yet, it is difficult to observe and objectively measure how affect evolves over time with sufficient resolution. Here, we suggest an approach that combines free association networks with affect mapping, to gain insight into basic patterns of affect dynamics. This approach exploits the established connection in the literature between association networks and behaviour. Using extant rich data, we find consistent patterns of the dynamics of the valence and arousal dimensions of affect. First, we find that the individuals represented by the data tend to feel a constant pull towards an affect-neutral global equilibrium point in the valence-arousal space. The farther the affect is from that point, the stronger the pull. We find that the drift of affect exhibits high inertia, i.e. is slow-changing, but with occasional discontinuous jumps of valence. We further find that, under certain conditions, another metastable equilibrium point emerges on the network, but one which represents a much more negative and agitated state of affect. Finally, we demonstrate how the affect-coded association network can be used to identify useful or harmful trajectories of associative thoughts that otherwise are hard to extract.

SUBMITTER: Dover Y

PROVIDER: S-EPMC7209140 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:Gene duplication with subsequent interaction divergence is one of the primary driving forces in the evolution of genetic systems. Yet little is known about the precise mechanisms and the role of duplication divergence in the evolution of protein networks from the prokaryote and eukaryote domains. We developed a novel, model-based approach for Bayesian inference on biological network data that centres on approximate Bayesian computation, or likelihood-free inference. Instead of computing the intractable likelihood of the protein network topology, our method summarizes key features of the network and, based on these, uses a MCMC algorithm to approximate the posterior distribution of the model parameters. This allowed us to reliably fit a flexible mixture model that captures hallmarks of evolution by gene duplication and subfunctionalization to protein interaction network data of Helicobacter pylori and Plasmodium falciparum. The 80% credible intervals for the duplication-divergence component are [0.64, 0.98] for H. pylori and [0.87, 0.99] for P. falciparum. The remaining parameter estimates are not inconsistent with sequence data. An extensive sensitivity analysis showed that incompleteness of PIN data does not largely affect the analysis of models of protein network evolution, and that the degree sequence alone barely captures the evolutionary footprints of protein networks relative to other statistics. Our likelihood-free inference approach enables a fully Bayesian analysis of a complex and highly stochastic system that is otherwise intractable at present. Modelling the evolutionary history of PIN data, it transpires that only the simultaneous analysis of several global aspects of protein networks enables credible and consistent inference to be made from available datasets. Our results indicate that gene duplication has played a larger part in the network evolution of the eukaryote than in the prokaryote, and suggests that single gene duplications with immediate divergence alone may explain more than 60% of biological network data in both domains.

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Using free association networks to extract characteristic patterns of affect dynamics.

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