Browse
Submit Data
Databases
API
Help

Dataset Information

8 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Consequences of undetected olfactory loss for human chemosensory communication and well-being.

ABSTRACT: Olfactory perception has implications for human chemosensory communication and in a broader context, it affects well-being. However, most of the studies investigating the consequences of olfactory loss have recruited patients who have already been categorized as having a dysfunctional sense of smell and sought help in an ENT clinic. We revisit these findings by distinguishing subjects with olfactory impairment from a group of subjects who all declared a normal sense of smell when enrolling for this study. In the initial sample of 203 individuals, we found 59 to have impaired olfaction and four with marginal olfactory performance, not useful in daily life. Interestingly, we found a significant between-group difference in cognitive functioning, further supporting the notion of the relationship between cognition and olfactory performance. However, their chemosensory communication and well-being appeared not to be different from subjects with normosmia. Impaired olfactory function certainly has a severe impact on daily life but more so in individuals who are bothered with it and decide to seek treatment. The limited-to-no olfactory perception in the fraction of subjects who neither complain about it nor seek help in ENT clinics does not seem to have a major effect on their social, cognitive, emotional and health functioning. This article is part of the Theo Murphy meeting issue 'Olfactory communication in humans'.

SUBMITTER: Oleszkiewicz A

PROVIDER: S-EPMC7209944 | biostudies-literature |

REPOSITORIES: biostudies-literature

ACCESS DATA

Json Xml

Similar Datasets

Evaluation of idiopathic olfactory loss with chemosensory event-related potentials and magnetic resonance imaging.

Project description:BACKGROUND:Idiopathic olfactory loss (IOL) accounts for a sizable fraction of olfactory dysfunction, but very little is known about its etiology and electrophysiological changes in the olfactory pathway. METHODS:We analyzed the physiology of IOL using chemosensory event-related potentials (ERPs) (olfactory and trigeminal: oERP and tERP) and olfactory pathway magnetic resonance imaging (MRI) measured in adult patients with IOL and healthy controls. Subjective olfactory function was measured by Toyota and Takagi (T&T) olfactometry and Sniffin' Sticks (SS). RESULTS:Olfactory function was worse in patients with IOL compared to controls (T&T, p < 0.001; SS, p < 0.001). oERPs could be evoked in 17 IOL patients. Signals in these patients showed lower amplitude in the N1 and P2 waves than controls (p < 0.05 for both), but there were no difference in latency between the 2 groups (p > 0.05). tERP were detected in all patients and controls; there were no differences in latency and nor amplitude between the 2 groups (p > 0.05). The olfactory bulb (OB) volume was significantly smaller in the IOL group than controls (p < 0.001), but there was no difference in the olfactory sulcus depth between groups (p > 0.05). Better olfactory function was associated with increasing magnitude of N1 amplitude in oERPs (p < 0.05) and increasing OB volume (p < 0.05). CONCLUSION:IOL patients show neurophysiologic deficits and some anatomic differences compared to healthy controls.

| S-EPMC6282607 | biostudies-other

Impacts of video communication on psychological well-being and cosmetic surgery acceptance

Project description:Video communication via platforms such as Zoom has been routinely used as a communication tool during the COVID-19 pandemic. Scientific evidence has suggested that constant video communication can have detrimental consequences such as “Zoom fatigue”, inhibiting collaboration, and new information exchange. The current study focuses on the effects of using video communication technology on self-esteem, affect, and image perception under the framework of objective self-awareness (OSA). We implemented a survey among a large sample of video communication users. The results revealed a nuanced picture of OSA with video communication: merely seeing self-video and the time of using video communication won't activate OSA. However, being a listener and a part of the audience in video communication activated OSA. In turn, OSA significantly increased the attention paid to oneself, leading to critical self-evaluation, negative affect, and a greater level of cosmetic surgery acceptance. Moreover, OSA reduced the level of self-esteem. Theoretical and practical implications are discussed.

| S-EPMC9771703 | biostudies-literature

Contribution of Model Organisms to Investigating the Far-Reaching Consequences of PRPP Metabolism on Human Health and Well-Being.

Project description:Phosphoribosyl pyrophosphate synthetase (PRS EC 2.7.6.1) is a rate-limiting enzyme that irreversibly catalyzes the formation of phosphoribosyl pyrophosphate (PRPP) from ribose-5-phosphate and adenosine triphosphate (ATP). This key metabolite is required for the synthesis of purine and pyrimidine nucleotides, the two aromatic amino acids histidine and tryptophan, the cofactors nicotinamide adenine dinucleotide (NAD+) and nicotinamide adenine dinucleotide phosphate (NADP+), all of which are essential for various life processes. Despite its ubiquity and essential nature across the plant and animal kingdoms, PRPP synthetase displays species-specific characteristics regarding the number of gene copies and architecture permitting interaction with other areas of cellular metabolism. The impact of mutated PRS genes in the model eukaryote Saccharomyces cerevisiae on cell signalling and metabolism may be relevant to the human neuropathies associated with PRPS mutations. Human PRPS1 and PRPS2 gene products are implicated in drug resistance associated with recurrent acute lymphoblastic leukaemia and progression of colorectal cancer and hepatocellular carcinoma. The investigation of PRPP metabolism in accepted model organisms, e.g., yeast and zebrafish, has the potential to reveal novel drug targets for treating at least some of the diseases, often characterized by overlapping symptoms, such as Arts syndrome and respiratory infections, and uncover the significance and relevance of human PRPS in disease diagnosis, management, and treatment.

| S-EPMC9221600 | biostudies-literature

Land cover matters to human well-being.

Project description:People migrate from rural to urban areas. In the meantime, the benefits of staying in greener areas are also known. People's preferences might be different by area that is composed of several land types. If so, the effect of particular land cover on human well-being is different spatially. The spatial analysis is required to formulate effective land-use policies. Here we show that urban land, water, and grassland are positively related to human well-being, whereas bare land is negatively associated in Japan. A 1 [Formula: see text] increase in the area of urban land per capita in a city is equivalent to an about 346 USD increase in the individual annual income of all the people in the city. Additionally, monetary values of areas of water, crops, and bare land per capita are 102, - 30, and - 268 [Formula: see text]. Furthermore, the spatial context matters to the relationship between land cover and human well-being. This paper investigates the monetary values of several land types and their spatial variability, which provides insights to make better usage for land cover.

| S-EPMC8342716 | biostudies-literature

Pandemic Impacts on Communication and Social Well-Being: Consideration for Individuals D/HH

Project description:The purpose of the current study was to investigate the impact of COVID-19 restrictions (e.g., face mask wearing and social distancing) on individuals who are Deaf or Hard of Hearing (D/HH). The study aimed to describe perceptions of challenges and valued resources to inform efforts to mitigate negative consequences of the pandemic. A survey was used to solicit information about the pandemic-related experiences of 108 individuals who are D/HH and/or parents or service providers of children who are D/HH. Questions elicited perceptions of pandemic related challenges, resources, and supports. Results demonstrated high percentages of respondents reported experiencing substantial impacts of face mask wearing on communication. Additionally, respondents reported negative consequences of social distancing on the way they connected with others. Findings point to the need for increased awareness of risks for impacts on communication and social well-being and consideration of additional supports.

| S-EPMC10323496 | biostudies-literature

Consequences of Circadian Disruption in Shift Workers on Chrononutrition and their Psychosocial Well-Being.

Project description:The workers and employees in various institutions are subjected to different shifts and work schedules. The employees work not only at daytime but also during odd hours at night. The biological clock of an individual is often altered during night shifts. This affects the psychosocial well-being and circadian nutritional intake of the worker. Disturbance in circadian rhythm results in the development of metabolic disorders such as hypertension, dyslipidemia, dysglycemia, and abdominal obesity. In the present review, we discuss the nature of shift work, sleep/wake cycle of an individual, chrononutrition, dietary habits, and meal changes with regard to timing and frequency, related to shift work. We also discuss the relationship between nutritional intake and psychosocial well-being among shift workers. The review may be beneficial for prevention of metabolic disorders and maintaining sound psychological condition in shift workers.

| S-EPMC7142532 | biostudies-literature

Human olfactory communication: current challenges and future prospects.

Project description:Although anthropologists frequently report the centrality of odours in the daily lives and cultural beliefs of many small-scale communities, Western scholars have historically considered the sense of smell as minimally involved in human communication. Here, we suggest that the origin and persistence of this latter view might be a consequence of the fact that most research is conducted on participants from Western societies who, collectively, were rather old (adults), deodorized and desensitized (ODD) to various aspects of olfactory perception. The view is rapidly changing, however, and this themed issue provides a timely overview of the current state-of-the-art on human chemocommunication. Based on evolutionary models of communication, the papers cover both general mechanisms of odour production by 'senders' and odour perception by 'receivers'. Focus on specific functional contexts includes reciprocal impact of odours between infants and mothers, the role of odour in mate choice and how odours communicate emotion and disease. Finally, a position paper outlines pitfalls and opportunities for the future, against the context of the replication crisis in psychology. We believe a more nuanced view of human chemical communication is within our grasp if we can continue to develop inter-disciplinary insights and expand research activities beyond ODD people. This article is part of the Theo Murphy meeting issue 'Olfactory communication in humans'.

| S-EPMC7209938 | biostudies-literature

Gain or loss? The well-being of women in self-employment.

Project description:Using data from the Chinese Household Income Project survey, we find that self-employed women have lower levels of well-being compared with their male counterparts. When comparing individuals' well-being in self-employment and wage-employment, we discover that self-employed men have higher levels of health, the standard of living, satisfaction, and life satisfaction compared with wage-employed men, whereas self-employed women have lower levels of health and life satisfaction than their counterparts in wage-employment. Furthermore, if a given self-employed man or woman had been selected for wage employment, their well-being would not improve (controlling for individual characteristics that affect the likelihood to enter self-employment). Hence, self-employed women face a double challenge: lower well-being than both self-employed men and wage-employed women. The article discusses recommendations for future research and policy implications.

| S-EPMC9523742 | biostudies-literature

A functional genomic perspective on human well-being.

Project description:To identify molecular mechanisms underlying the prospective health advantages associated with psychological well-being, we analyzed leukocyte basal gene expression profiles in 80 healthy adults who were assessed for hedonic and eudaimonic well-being, as well as potentially confounded negative psychological and behavioral factors. Hedonic and eudaimonic well-being showed similar affective correlates but highly divergent transcriptome profiles. Peripheral blood mononuclear cells from people with high levels of hedonic well-being showed up-regulated expression of a stress-related conserved transcriptional response to adversity (CTRA) involving increased expression of proinflammatory genes and decreased expression of genes involved in antibody synthesis and type I IFN response. In contrast, high levels of eudaimonic well-being were associated with CTRA down-regulation. Promoter-based bioinformatics implicated distinct patterns of transcription factor activity in structuring the observed differences in gene expression associated with eudaimonic well-being (reduced NF-?B and AP-1 signaling and increased IRF and STAT signaling). Transcript origin analysis identified monocytes, plasmacytoid dendritic cells, and B lymphocytes as primary cellular mediators of these dynamics. The finding that hedonic and eudaimonic well-being engage distinct gene regulatory programs despite their similar effects on total well-being and depressive symptoms implies that the human genome may be more sensitive to qualitative variations in well-being than are our conscious affective experiences.

| S-EPMC3746929 | biostudies-literature

Diversity of network communication mode and interpersonal interactions: Relationship with social support and well-being.

Project description:Social interactions today expand beyond in-person interactions. Therefore, it is important to recognize that social interactions can occur with social network members across multiple communication modes (in-person, phone, and online). The current study explored the role that social support plays in the relationship between mode frequency (in-person, phone, and online), network communication mode diversity (breadth and evenness of communicating with network members via different communication modes), and well-being (positive affect, stress, and loneliness) from the 3-year UCNET (UC Berkley Social Networks Study, N = 1159) dataset. The study contained samples for two age groups (cohorts) - 21-31 year-olds and 50-70 year-olds, which also allowed for an exploration of age differences in these relationships. Longitudinal random-intercept cross-lagged panel models (RI-CLPM) showed a high degree of stability over the 3 years for all variables. Cross-sectional structural equation mediation models showed that social support mediated the relationships of mode frequency (in-person, phone, and online) and network communication mode diversity with well-being (more positive affect and less loneliness and stress). Age differences were found in the relationship between frequency of communication modes and social support, in that the frequency of communication mode was positively related to social support for younger adults, but not for middle-aged/older adults. Current findings provided future research directions geared toward further understanding of the mode frequency and network communication mode diversity constructs and how they relate to various psychosocial outcomes.

| S-EPMC10852044 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data