Genome-wide association study of shared liability to anxiety disorders in Army STARRS.

ABSTRACT: Anxiety disorders (ANX), namely generalized anxiety, panic disorder, and phobias, are common, etiologically complex syndromes that show increasing prevalence and comorbidity throughout adolescence and beyond. Few genome-wide association studies (GWAS) examining ANX risk have been published and almost exclusively in individuals of European ancestry. In this study, we phenotyped participants from the Army Study To Assess Risk and Resilience in Servicemembers (STARRS) to approximate DSM-based ANX diagnoses. We factor-analyzed those to create a single dimensional anxiety score for each subject. GWAS were conducted using that score within each of three ancestral groups (EUR, AFR, LAT) and then meta-analyzed across ancestries (N_Total = 16,510). We sought to (a) replicate prior ANX GWA

SUBMITTER: Hettema JM 

PROVIDER: S-EPMC7210051 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature