Ontology highlight
ABSTRACT:
SUBMITTER: Beckwith KS
PROVIDER: S-EPMC7210277 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200508 1
Mycobacterium tuberculosis is a global health problem in part as a result of extensive cytotoxicity caused by the infection. Here, we show how M. tuberculosis causes caspase-1/NLRP3/gasdermin D-mediated pyroptosis of human monocytes and macrophages. A type VII secretion system (ESX-1) mediated, contact-induced plasma membrane damage response occurs during phagocytosis of bacteria. Alternatively, this can occur from the cytosolic side of the plasma membrane after phagosomal rupture in infected ma ...[more]