Ontology highlight
ABSTRACT:
SUBMITTER: Piai A
PROVIDER: S-EPMC7210310 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nature communications 20200508 1
The prefusion conformation of HIV-1 envelope protein (Env) is recognized by most broadly neutralizing antibodies (bnAbs). Studies showed that alterations of its membrane-related components, including the transmembrane domain (TMD) and cytoplasmic tail (CT), can reshape the antigenic structure of the Env ectodomain. Using nuclear magnetic resonance (NMR) spectroscopy, we determine the structure of an Env segment encompassing the TMD and a large portion of the CT in bicelles. The structure reveals ...[more]