CARGEL Bioscaffold improves cartilage repair tissue after bone marrow stimulation in a minipig model.

ABSTRACT: PURPOSE:To gain knowledge of the repair tissue in critically sized cartilage defects using bone marrow stimulation combined with CARGEL Bioscaffold (CB) compared with bone marrow stimulation (BMS) alone in a validated animal model. METHODS:Six adult Göttingen minipigs received two chondral defects in each knee. The knees were randomized to either BMS combined with CB or BMS alone. The animals were euthanized after 6 months. Follow-up consisted of histomorphometry, immunohistochemistry, semiquantitative scoring of the repair tissue (ICRS II), and μCT of the trabecular bone beneath the defect. RESULTS:There was significantly more fibrocartilage (80% vs 64%, p = 0.04) and a trend towards less fibrous tissue (15% vs 30%, p = 0.05) in the defects treated with CB. Hyaline cartilage was only seen

SUBMITTER: Hede K 

PROVIDER: S-EPMC7210369 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature