Avidin-biotin technology to synthesize multi-arm nano-construct for drug delivery.
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ABSTRACT:
SUBMITTER: Zhang C
PROVIDER: S-EPMC7210587 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Avidin-biotin technology to synthesize multi-arm nano-construct for drug delivery.
Zhang Chenzhen C He Tengfei T Vedadghavami Armin A Bajpayee Ambika G AG
MethodsX 20200422
Here we describe methods for synthesizing a cationic, multi-arm Avidin (mAv) nano-construct that has a wide range of applications in drug delivery and imaging of negatively charged tissues. We use Avidin-biotin technology that gives the flexibility for conjugating biotinylated Dexamethasone to mAv by simple mixing at room temperature. We also describe methods to control hydrolysis rates of ester linkers to enable sustained (and tunable) drug release rates in therapeutic doses.•Multi-arm structur ...[more]
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