Ontology highlight
ABSTRACT:
SUBMITTER: Ivanova T
PROVIDER: S-EPMC7210879 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Ivanova Tsvetomira T Maier Michael M Missarova Alsu A Ziegler-Birling Céline C Dam Monica M Gomar-Alba Mercè M Carey Lucas B LB Mendoza Manuel M
Nature communications 20200508 1
To faithfully transmit genetic information, cells must replicate their entire genome before division. This is thought to be ensured by the temporal separation of replication and chromosome segregation. Here we show that in 20-40% of unperturbed yeast cells, DNA synthesis continues during anaphase, late in mitosis. High cyclin-Cdk activity inhibits DNA synthesis in metaphase, and the decrease in cyclin-Cdk activity during mitotic exit allows DNA synthesis to finish at subtelomeric and some diffic ...[more]