A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.
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ABSTRACT:
SUBMITTER: Shen X
PROVIDER: S-EPMC7210889 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Publications
A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.
Shen Xueyi X Howard David M DM Adams Mark J MJ Hill W David WD Clarke Toni-Kim TK Deary Ian J IJ Whalley Heather C HC McIntosh Andrew M AM
Nature communications 20200508 1
Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replicati ...[more]
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