Ontology highlight
ABSTRACT:
SUBMITTER: Piazza VG
PROVIDER: S-EPMC7211091 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Piazza Verónica G VG Matzkin María E ME Cicconi Nadia S NS Muia Nadia V NV Valquinta Sofía S Mccallum Gregorio J GJ Micucci Giannina P GP Freund Thomas T Zotta Elsa E González Lorena L Frungieri Mónica B MB Fang Yimin Y Bartke Andrzej A Sotelo Ana I AI Miquet Johanna G JG
Molecular and cellular endocrinology 20200404
Continuously elevated levels of growth hormone (GH) during life in mice are associated with hepatomegaly due to hepatocytes hypertrophy and hyperplasia, chronic liver inflammation, elevated levels of arachidonic acid (AA) at young ages and liver tumors development at old ages. In this work, the hepatic expression of enzymes involved in AA metabolism, cPLA2α, COX1 and COX2 enzymes, was evaluated in young and old GH-transgenic mice. Mice overexpressing GH exhibited higher hepatic expression of cPL ...[more]