An individualized mosaic of maternal microbial strains is transmitted to the infant gut microbial community.

ABSTRACT: To understand the origins of the infant gut microbial community, we have used a published metagenomic dataset of the faecal microbiome of mothers and their related infants at early (4, 7 and 21 days) and late times (6-15 months) following birth. Using strain-tracking analysis, individual-specific patterns of microbial strain sharing were found between mothers and infants following vaginal birth. Overall, three mother-infant pairs showed only related strains, while 12 infants of mother-infant pairs contained a mosaic of maternal-related and unrelated microbes. Analysis of a second dataset from nine women taken at different times of pregnancy revealed individual-specific faecal microbial strain variation that occurred in seven women. To model transmission in the absence of environmental micr

SUBMITTER: Koo H 

PROVIDER: S-EPMC7211887 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature