The invasive proteome of glioblastoma revealed by laser-capture microdissection.
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ABSTRACT:
SUBMITTER: Daubon T
PROVIDER: S-EPMC7212852 | biostudies-literature | 2019 May-Dec
REPOSITORIES: biostudies-literature
Publications
The invasive proteome of glioblastoma revealed by laser-capture microdissection.
Daubon Thomas T Guyon Joris J Raymond Anne-Aurélie AA Dartigues Benjamin B Rudewicz Justine J Ezzoukhry Zakaria Z Dupuy Jean-William JW Herbert John M J JMJ Saltel Frédéric F Bjerkvig Rolf R Nikolski Macha M Bikfalvi Andreas A
Neuro-oncology advances 20190501 1
<h4>Background</h4>Glioblastomas are heterogeneous tumors composed of a necrotic and tumor core and an invasive periphery.<h4>Methods</h4>Here, we performed a proteomics analysis of laser-capture micro-dissected glioblastoma core and invasive areas of patient-derived xenografts.<h4>Results</h4>Bioinformatics analysis identified enriched proteins in central and invasive tumor areas. Novel markers of invasion were identified, the genes proteolipid protein 1 (PLP1) and Dynamin-1 (DNM1), which were ...[more]
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