Ontology highlight
ABSTRACT:
SUBMITTER: Pearson CM
PROVIDER: S-EPMC7213271 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20190628 31
Herein, we report a modular synthetic route to linear and branched homoallylic amines that operates through a sequential one-pot Lewis base/transition-metal catalyzed allylic alkylation/Hofmann rearrangement strategy. This protocol is operationally trivial, proceeds from simple and easily prepared substrates and catalysts, and enables all aspects of regio- and stereoselectivity to be controlled through a conserved experimental protocol. Overall, the high levels of enantio-, regio-, and diastereo ...[more]