Ontology highlight
ABSTRACT:
SUBMITTER: Nakayama A
PROVIDER: S-EPMC7213308 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Nakayama Akiyoshi A Nakatochi Masahiro M Kawamura Yusuke Y Yamamoto Ken K Nakaoka Hirofumi H Shimizu Seiko S Higashino Toshihide T Koyama Teruhide T Hishida Asahi A Kuriki Kiyonori K Watanabe Miki M Shimizu Toru T Ooyama Keiko K Ooyama Hiroshi H Nagase Mitsuo M Hidaka Yuji Y Matsui Daisuke D Tamura Takashi T Nishiyama Takeshi T Shimanoe Chisato C Katsuura-Kamano Sakurako S Takashima Naoyuki N Shirai Yuya Y Kawaguchi Makoto M Takao Mikiya M Sugiyama Ryo R Takada Yuzo Y Nakamura Takahiro T Nakashima Hiroshi H Tsunoda Masashi M Danjoh Inaho I Hozawa Atsushi A Hosomichi Kazuyoshi K Toyoda Yu Y Kubota Yu Y Takada Tappei T Suzuki Hiroshi H Stiburkova Blanka B Major Tanya J TJ Merriman Tony R TR Kuriyama Nagato N Mikami Haruo H Takezaki Toshiro T Matsuo Keitaro K Suzuki Sadao S Hosoya Tatsuo T Kamatani Yoichiro Y Kubo Michiaki M Ichida Kimiyoshi K Wakai Kenji K Inoue Ituro I Okada Yukinori Y Shinomiya Nariyoshi N Matsuo Hirotaka H
Annals of the rheumatic diseases 20200401 5
<h4>Objectives</h4>Genome-wide meta-analyses of clinically defined gout were performed to identify subtype-specific susceptibility loci. Evaluation using selection pressure analysis with these loci was also conducted to investigate genetic risks characteristic of the Japanese population over the last 2000-3000 years.<h4>Methods</h4>Two genome-wide association studies (GWASs) of 3053 clinically defined gout cases and 4554 controls from Japanese males were performed using the Japonica Array and Il ...[more]