Global ocean resistome revealed: Exploring antibiotic resistance gene abundance and distribution in TARA Oceans samples.

ABSTRACT:

Background

The rise of antibiotic resistance (AR) in clinical settings is of great concern. Therefore, the understanding of AR mechanisms, evolution, and global distribution is a priority for patient survival. Despite all efforts in the elucidation of AR mechanisms in clinical strains, little is known about its prevalence and evolution in environmental microorganisms. We used 293 metagenomic samples from the TARA Oceans project to detect and quantify environmental antibiotic resistance genes (ARGs) using machine learning tools.

Results

After manual curation of ARGs, their abundance and distribution in the global ocean are presented. Additionally, the potential of horizontal ARG transfer by plasmids and their correlation with environmental and geographical parameters is shown

SUBMITTER: Cuadrat RRC 

PROVIDER: S-EPMC7213576 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature