Ontology highlight
ABSTRACT:
SUBMITTER: Riehle C
PROVIDER: S-EPMC7213803 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Riehle Christian C Weatherford Eric T ET Wende Adam R AR Jaishy Bharat P BP Seei Alec W AW McCarty Nicholas S NS Rech Monika M Shi Qian Q Reddy Gopireddy R GR Kutschke William J WJ Oliveira Karen K Pires Karla Maria KM Anderson Joshua C JC Diakos Nikolaos A NA Weiss Robert M RM White Morris F MF Drakos Stavros G SG Xiang Yang K YK Abel E Dale ED
JCI insight 20200326 6
Pressure overload (PO) cardiac hypertrophy and heart failure are associated with generalized insulin resistance and hyperinsulinemia, which may exacerbate left ventricular (LV) remodeling. While PO activates insulin receptor tyrosine kinase activity that is transduced by insulin receptor substrate 1 (IRS1), the present study tested the hypothesis that IRS1 and IRS2 have divergent effects on PO-induced LV remodeling. We therefore subjected mice with cardiomyocyte-restricted deficiency of IRS1 (CI ...[more]