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Metabolic reprogramming-associated genes predict overall survival for rectal cancer.


ABSTRACT: Metabolic reprogramming has become a hot topic recently in the regulation of tumour biology. Although hundreds of altered metabolic genes have been reported to be associated with tumour development and progression, the important prognostic role of these metabolic genes remains unknown. We downloaded messenger RNA expression profiles and clinicopathological data from The Cancer Genome Atlas and the Gene Expression Omnibus database to uncover the prognostic role of these metabolic genes. Univariate Cox regression analysis and lasso Cox regression model were utilized in this study to screen prognostic associated metabolic genes. Patients with high-risk demonstrated significantly poorer survival outcomes than patients with low-risk in the TCGA database. Also, patients with high-risk still showed significantly poorer survival outcomes than patients with low-risk in the GEO database. What is more, gene set enrichment analyses were performed in this study to uncover significantly enriched GO terms and pathways in order to help identify potential underlying mechanisms. Our study identified some survival-related metabolic genes for rectal cancer prognosis prediction. These genes might play essential roles in the regulation of metabolic microenvironment and in providing significant potential biomarkers in metabolic treatment.

SUBMITTER: Zhang ZY 

PROVIDER: S-EPMC7214181 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Metabolic reprogramming-associated genes predict overall survival for rectal cancer.

Zhang Zhong-Yi ZY   Yao Qing-Zhi QZ   Liu Hui-Yong HY   Guo Qiao-Nan QN   Qiu Peng-Jun PJ   Chen Jian-Peng JP   Lin Jian-Qing JQ  

Journal of cellular and molecular medicine 20200413 10


Metabolic reprogramming has become a hot topic recently in the regulation of tumour biology. Although hundreds of altered metabolic genes have been reported to be associated with tumour development and progression, the important prognostic role of these metabolic genes remains unknown. We downloaded messenger RNA expression profiles and clinicopathological data from The Cancer Genome Atlas and the Gene Expression Omnibus database to uncover the prognostic role of these metabolic genes. Univariat  ...[more]

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