Ontology highlight
ABSTRACT:
SUBMITTER: Elvarsdottir EM
PROVIDER: S-EPMC7214248 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Elvarsdóttir Edda María EM Mortera-Blanco Teresa T Dimitriou Marios M Bouderlique Thibault T Jansson Monika M Hofman Isabel Juliana F IJF Conte Simona S Karimi Mohsen M Sander Birgitta B Douagi Iyadh I Woll Petter S PS Hellström-Lindberg Eva E
Leukemia 20190802 1
Established cell culture systems have failed to accurately recapitulate key features of terminal erythroid maturation, hampering our ability to in vitro model and treat diseases with impaired erythropoiesis such as myelodysplastic syndromes with ring sideroblasts (MDS-RS). We developed an efficient and robust three-dimensional (3D) scaffold culture model supporting terminal erythroid differentiation from both mononuclear (MNC) or CD34<sup>+</sup>-enriched primary bone marrow cells from healthy d ...[more]