Ontology highlight
ABSTRACT:
SUBMITTER: Averitt AJ
PROVIDER: S-EPMC7214444 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Averitt Amelia J AJ Weng Chunhua C Ryan Patrick P Perotte Adler A
NPJ digital medicine 20200511
Randomized controlled trials (RCTs) are regarded as the most reputable source of evidence. In some studies, factors beyond the intervention itself may contribute to the measured effect, an occurrence known as heterogeneity of treatment effect (HTE). If the RCT population differs from the real-world population on factors that induce HTE, the trials effect will not replicate. The RCTs eligibility criteria should identify the sub-population in which its evidence will replicate. However, the extent ...[more]