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Impact of needle-based confocal laser endomicroscopy on the therapeutic management of single pancreatic cystic lesions.


ABSTRACT: BACKGROUND AND AIM:The diagnosis and therapeutic management of large single pancreatic cystic lesions (PCLs) represent major issues for clinicians and essentially rely on endoscopic ultrasound fine-needle aspiration (EUS-FNA) findings. Needle-based confocal laser endomicroscopy (nCLE) has high diagnostic performance for PCLs. This study aimed to evaluate the impact of nCLE on the therapeutic management of patients with single PCLs. METHODS:Retrospective and comparative study. Five independent pancreatic disease experts from tertiary hospitals independently reviewed data from a prospective database of 206 patients with single PCL, larger than 2 cm and who underwent EUS-FNA and nCLE. Two evaluations were performed. The first one included the sequential review of clinical information, EUS report and FNA results. The second one included the same data?+?nCLE report. Participants had to propose a therapeutic management for each case. RESULTS:The addition of nCLE to EUS-FNA led to significant changes in therapeutic management for 28% of the patients (p?

SUBMITTER: Palazzo M 

PROVIDER: S-EPMC7214514 | biostudies-literature | 2020 Jun

REPOSITORIES: biostudies-literature

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<h4>Background and aim</h4>The diagnosis and therapeutic management of large single pancreatic cystic lesions (PCLs) represent major issues for clinicians and essentially rely on endoscopic ultrasound fine-needle aspiration (EUS-FNA) findings. Needle-based confocal laser endomicroscopy (nCLE) has high diagnostic performance for PCLs. This study aimed to evaluate the impact of nCLE on the therapeutic management of patients with single PCLs.<h4>Methods</h4>Retrospective and comparative study. Five  ...[more]

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