Ontology highlight
ABSTRACT:
SUBMITTER: Jefri M
PROVIDER: S-EPMC7214648 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Jefri Malvin M Bell Scott S Peng Huashan H Hettige Nuwan N Maussion Gilles G Soubannier Vincent V Wu Hanrong H Silveira Heika H Theroux Jean-Francois JF Moquin Luc L Zhang Xin X Aouabed Zahia Z Krishnan Jeyashree J O'Leary Liam A LA Antonyan Lilit L Zhang Ying Y McCarty Vincent V Mechawar Naguib N Gratton Alain A Schuppert Andreas A Durcan Thomas M TM Fon Edward A EA Ernst Carl C
Stem cells translational medicine 20200310 6
Making high-quality dopamine (DA)-producing cells for basic biological or small molecule screening studies is critical for the development of novel therapeutics for disorders of the ventral midbrain. Currently, many ventral midbrain assays have low signal-to-noise ratio due to low levels of cellular DA and the rate-limiting enzyme of DA synthesis, tyrosine hydroxylase (TH), hampering discovery efforts. Using intensively characterized ventral midbrain cells derived from human skin, which demonstr ...[more]