Ontology highlight
ABSTRACT:
SUBMITTER: Kohlmeyer JL
PROVIDER: S-EPMC7215455 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Kohlmeyer Jordan L JL Gordon David J DJ Tanas Munir R MR Monga Varun V Dodd Rebecca D RD Quelle Dawn E DE
International journal of molecular sciences 20200424 8
Sarcomas represent one of the most challenging tumor types to treat due to their diverse nature and our incomplete understanding of their underlying biology. Recent work suggests cyclin-dependent kinase (CDK) pathway activation is a powerful driver of sarcomagenesis. CDK proteins participate in numerous cellular processes required for normal cell function, but their dysregulation is a hallmark of many pathologies including cancer. The contributions and significance of aberrant CDK activity to sa ...[more]