Matrix Metalloproteinases: How Much Can They Do?
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ABSTRACT:
SUBMITTER: Agren MS
PROVIDER: S-EPMC7215854 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Publications
Matrix Metalloproteinases: How Much Can They Do?
Ågren Magnus S MS Auf dem Keller Ulrich U
International journal of molecular sciences 20200412 8
Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a disintegrin and metalloproteinase domain) and 19 secreted ADAMTSs (a disintegrin and metalloproteinase thrombospondin domain). The many setbacks from the clinical trials of broad-spectrum MMP inhibitors for cancer indications in the late 1990s emphasized the extreme complexity of the participation of these proteolytic enzymes in bi ...[more]
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