Ontology highlight
ABSTRACT:
SUBMITTER: Di Biase E
PROVIDER: S-EPMC7215935 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Di Biase Erika E Lunghi Giulia G Maggioni Margherita M Fazzari Maria M Pomè Diego Yuri DY Loberto Nicoletta N Ciampa Maria Grazia MG Fato Pamela P Mauri Laura L Sevin Emmanuel E Gosselet Fabien F Sonnino Sandro S Chiricozzi Elena E
International journal of molecular sciences 20200419 8
Ganglioside GM1 (GM1) has been reported to functionally recover degenerated nervous system in vitro and in vivo, but the possibility to translate GM1's potential in clinical settings is counteracted by its low ability to overcome the blood-brain barrier (BBB) due to its amphiphilic nature. Interestingly, the soluble and hydrophilic GM1-oligosaccharide (OligoGM1) is able to punctually replace GM1 neurotrophic functions alone, both in vitro and in vivo. In order to take advantage of OligoGM1 prope ...[more]