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Gender Predilection in Sporadic Parathyroid Adenomas.


ABSTRACT: Primary hyperparathyroidism is a common endocrinopathy that is mainly caused by benign parathyroid adenomas. The frequency, clinical presentation and complications of the disease show significant differences between genders, with the majority of cases being reported in postmenopausal women. Due to this gender predilection, several studies have investigated the role of sex hormones in the pathogenesis of the disease and their potential use as targets for optimal and gender-specific management. Epigenetic mechanisms that regulate gene transcription may also contribute to these differences between genders. In this review, we outline what is currently known regarding the role of sex hormones and the recent data on the role of non-coding RNAs in the differences between genders in primary hyperparathyroidism due to sporadic parathyroid adenomas.

SUBMITTER: Yavropoulou MP 

PROVIDER: S-EPMC7216151 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Gender Predilection in Sporadic Parathyroid Adenomas.

Yavropoulou Maria P MP   Anastasilakis Athanasios D AD   Panagiotakou Argyro A   Kassi Evanthia E   Makras Polyzois P  

International journal of molecular sciences 20200422 8


Primary hyperparathyroidism is a common endocrinopathy that is mainly caused by benign parathyroid adenomas. The frequency, clinical presentation and complications of the disease show significant differences between genders, with the majority of cases being reported in postmenopausal women. Due to this gender predilection, several studies have investigated the role of sex hormones in the pathogenesis of the disease and their potential use as targets for optimal and gender-specific management. Ep  ...[more]

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