Ontology highlight
ABSTRACT:
SUBMITTER: Wang WH
PROVIDER: S-EPMC7216183 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Wang Wen-Hung WH Yeh Chun-Sheng CS Lin Chih-Yen CY Yuan Ruei-Yu RY Urbina Aspiro Nayim AN Lu Po-Liang PL Chen Yen-Hsu YH Chen Yi-Ming Arthur YA Liu Fu-Tong FT Wang Sheng-Fan SF
International journal of molecular sciences 20200421 8
HIV-1 CRF07_BC is a recombinant virus with amino acid (a.a.) deletions in p6<sup>Gag</sup>, which are overlapped with the Alix-binding domain. Galectin-3 (Gal3), a β-galactose binding lectin, has been reported to interact with Alix and regulate HIV-1 subtype B budding. This study aims to evaluate the role of Gal3 in HIV-1 CRF07_BC infection and the potential effect of a.a. deletions on Gal3-mediated regulation. A total of 38 HIV-1+ injecting drug users (IDUs) were enrolled in the study. Viral ch ...[more]