Ontology highlight
ABSTRACT:
SUBMITTER: Hajek R
PROVIDER: S-EPMC7216833 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Hajek Roman R Pour Ludek L Ozcan Muhit M Martin Sánchez Jesus J García Sanz Ramon R Anagnostopoulos Achilles A Oriol Albert A Cascavilla Nicola N Terjung Andreas A Lee Yihua Y Briso Eva M EM Dobkowska Edyta E Hauns Bernhard B Špička Ivan I
European journal of haematology 20200307 5
<h4>Objective</h4>We evaluated ibrutinib, a once-daily inhibitor of Bruton's tyrosine kinase, combined with bortezomib and dexamethasone in patients with relapsed or relapsed/refractory multiple myeloma who had received 1-3 prior therapies.<h4>Methods</h4>This was a phase 2, single-arm, open-label, multicentre study (NCT02902965). The primary endpoint was progression-free survival (PFS).<h4>Results</h4>Seventy-six patients were enrolled; 74 received ≥1 dose of study treatment. After median follo ...[more]