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Metals in Biotechnology: Cr-Driven Stereoselective Reduction of Conjugated C=C Double Bonds.

ABSTRACT: Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although the latter excels by higher reaction rates. The general applicability of this new chemoenzymatic reduction method is demonstrated, and current limitations are outlined.

SUBMITTER: Rauch MCR

PROVIDER: S-EPMC7217005 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Metals in Biotechnology: Cr-Driven Stereoselective Reduction of Conjugated C=C Double Bonds.

Rauch Marine C R MCR Gallou Yann Y Delorme Léna L Paul Caroline E CE Arends Isabel W C E IWCE Hollmann Frank F

Chembiochem : a European journal of chemical biology 20191219 8

Elemental metals are shown to be suitable sacrificial electron donors to drive the stereoselective reduction of conjugated C=C double bonds using Old Yellow Enzymes as catalysts. Both direct electron transfer from the metal to the enzyme as well as mediated electron transfer is feasible, although the latter excels by higher reaction rates. The general applicability of this new chemoenzymatic reduction method is demonstrated, and current limitations are outlined. ...[more]

PMID: 31713969

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