Dataset Information

Results of the ADHERE upper airway stimulation registry and predictors of therapy efficacy.

ABSTRACT: OBJECTIVE/HYPOTHESIS:The ADHERE Registry is a multicenter prospective observational study following outcomes of upper airway stimulation (UAS) therapy in patients who have failed continuous positive airway pressure therapy for obstructive sleep apnea (OSA). The aim of this registry and purpose of this article were to examine the outcomes of patients receiving UAS for treatment of OSA. STUDY DESIGN:Cohort Study. METHODS:Demographic and sleep study data collection occurred at baseline, implantation visit, post-titration (6 months), and final visit (12 months). Patient and physician reported outcomes were also collected. Post hoc univariate and multivariate analysis was used to identify predictors of therapy response, defined as ?50% decrease in Apnea-Hypopnea Index (AHI) and AHI ?20 at the 12-month visit. RESULTS:The registry has enrolled 1,017 patients from October 2016 through February 2019. Thus far, 640 patients have completed their 6-month follow-up and 382 have completed the 12-month follow-up. After 12 months, median AHI was reduced from 32.8 (interquartile range [IQR], 23.6-45.0) to 9.5 (IQR, 4.0-18.5); mean, 35.8?±?15.4 to 14.2?±?15.0, P?

SUBMITTER: Thaler E

PROVIDER: S-EPMC7217178 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Results of the ADHERE upper airway stimulation registry and predictors of therapy efficacy.

Thaler Erica E Schwab Richard R Maurer Joachim J Soose Ryan R Larsen Christopher C Stevens Suzanne S Stevens Damien D Boon Maurits M Huntley Colin C Doghramji Karl K Waters Tina T Kominsky Alan A Steffen Armin A Kezirian Eric E Hofauer Benedikt B Sommer Ulrich U Withrow Kirk K Strohl Kingman K Heiser Clemens C

The Laryngoscope 20190914 5

<h4>Objective/hypothesis</h4>The ADHERE Registry is a multicenter prospective observational study following outcomes of upper airway stimulation (UAS) therapy in patients who have failed continuous positive airway pressure therapy for obstructive sleep apnea (OSA). The aim of this registry and purpose of this article were to examine the outcomes of patients receiving UAS for treatment of OSA.<h4>Study design</h4>Cohort Study.<h4>Methods</h4>Demographic and sleep study data collection occurred at ...[more]

PMID: 31520484

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Project description:BackgroundUpper extremity transplantation (UET) is becoming increasingly common. This article attempts to collate data from cases contributing to the International Registry on Hand and Composite Tissue Transplantation (IRHCTT), define psychosocial themes perceived as predictors of success using statistical methods, and provide an objective measure for optimization and selection of candidates.MethodsThe IRHCTT provided anonymous data on UET recipients. A supplementary psychosocial survey was developed focusing on themes of depression, posttraumatic stress disorder (PTSD), anxiety, interpersonal functioning and dependence, compliance, chronic pain, social support, quality of life, and patient expectations. We determined the risk of transplant loss and psychological factors associated with higher risk of transplant loss.ResultsSixty-two UET recipients reported to the IRHCTT. Forty-three psychosocial surveys (68%) were received, with 38 (88%) having intact transplants and 5 (12%) being amputated. Among recipients with a diagnosis of anxiety (N = 29, 67%), 5 (17%) reported transplant loss (P = 0.03). Among those with depression (N = 14, 33%), 2 recipients (14%) has transplant loss (P = 0.17); while 4 recipients (22%) with PTSD (N = 18, 42%) had transplant loss (P = 0.01). Of participants active in occupational therapy (N = 28, 65%), 2 (7%) reported transplant loss (P = 0.09). Of recipients with realistic functional expectations (N = 34, 79%), 2 (6%) had transplant loss versus 3 (34%) who were felt to not have realistic expectations (N = 9, 21%, P = 0.05). Recipients with strong family support (N = 33, 77%) had a lower risk of transplant loss compared with poor or fair family support (N = 10, 23%), but did not reach statistical significance (6% versus 30%, P = 0.14).ConclusionAnxiety, depression, PTSD, participation in occupational therapy, expectations for posttransplant function, and family support are associated with postsurgical transplant status.

Dataset Information

Results of the ADHERE upper airway stimulation registry and predictors of therapy efficacy.

Publications

Results of the ADHERE upper airway stimulation registry and predictors of therapy efficacy.

Similar Datasets

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