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Efficacy and Safety of Ertugliflozin in Patients with Overweight and Obesity with Type 2 Diabetes Mellitus.


ABSTRACT: OBJECTIVE:This study aimed to evaluate ertugliflozin in patients with overweight and obesity with type 2 diabetes mellitus. METHODS:Data from three placebo-controlled, randomized, Phase 3 studies were pooled. Patients with baseline BMI???25 (1,377/1,544; 89%) were assessed with a stratification by BMI subgroup. RESULTS:At week 26, reductions from baseline in glycated hemoglobin A1c (HbA1c), fasting plasma glucose, body weight (BW), and systolic blood pressure (SBP) were greater with ertugliflozin versus placebo. For placebo, ertugliflozin 5 mg, and ertugliflozin 15 mg, respectively, least squares mean change was 0.1%, -0.8%, and -0.9% for HbA1c and -1.2 kg, -3.1 kg, and -3.2 kg for BW. HbA1c reductions were consistent across BMI subgroups. For ertugliflozin 5 mg and 15 mg, least squares mean change (placebo adjusted) in absolute BW was -1.4 kg and -1.2 kg for BMI 25 to?

SUBMITTER: Heymsfield SB 

PROVIDER: S-EPMC7217180 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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Efficacy and Safety of Ertugliflozin in Patients with Overweight and Obesity with Type 2 Diabetes Mellitus.

Heymsfield Steven B SB   Raji Annaswamy A   Gallo Silvina S   Liu Jie J   Pong Annpey A   Hannachi Hakima H   Terra Steven G SG  

Obesity (Silver Spring, Md.) 20200401 4


<h4>Objective</h4>This study aimed to evaluate ertugliflozin in patients with overweight and obesity with type 2 diabetes mellitus.<h4>Methods</h4>Data from three placebo-controlled, randomized, Phase 3 studies were pooled. Patients with baseline BMI ≥ 25 (1,377/1,544; 89%) were assessed with a stratification by BMI subgroup.<h4>Results</h4>At week 26, reductions from baseline in glycated hemoglobin A1c (HbA1c), fasting plasma glucose, body weight (BW), and systolic blood pressure (SBP) were gre  ...[more]

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