Salvianolic Acid A Exhibits Anti-Inflammatory and Antiarthritic Effects via Inhibiting NF-?B and p38/MAPK Pathways.

ABSTRACT: Introduction:Osteoarthritis (OA), a chronic joint disease, combines with massive inflammation and plays a vital role in cartilage degeneration. The main strategy in clinic is controlling inflammation, thereby treating osteoarthritis. Salvianolic acid A (SAA) is a type of phenolic acid, derived from a traditional chinese herbal medicine Danshen that is extensively used clinically. Methods and Results:We observed the anti-inflammatory and antiarthritic effects of SAA in IL-1?-stimulated cells. We found that SAA evidently decreased the expression of mainly inflammatory factors, exerted the remarkable effects of anti-inflammation and anti-arthritis. Furthermore, SAA inhibited the expression of Matrix metalloproteinases (MMP1, MMP13), and ADAMTS-5 and raised the synthesis of collagen II and aggrecan. Additionally, the results indicated that SAA gave rise to the effects by down-regulation of NF-?B and p38/MAPK pathways. Discussion:Our study demonstrates that SAA may be a promising anti-inflammatory for the treatment of OA in clinic.

SUBMITTER: Feng S 

PROVIDER: S-EPMC7217308 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature