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Higher-Order Linearization and Regularity in Nonlinear Homogenization.

ABSTRACT: We prove large-scale C? regularity for solutions of nonlinear elliptic equations with random coefficients, thereby obtaining a version of the statement of Hilbert's 19th problem in the context of homogenization. The analysis proceeds by iteratively improving three statements together: (i) the regularity of the homogenized Lagrangian L¯ , (ii) the commutation of higher-order linearization and homogenization, and (iii) large-scale C0,1 -type regularity for higher-order linearization errors. We consequently obtain a quantitative estimate on the scaling of linearization errors, a Liouville-type theorem describing the polynomially-growing solutions of the system of higher-order linearized equations, and an explicit (heterogenous analogue of the) Taylor series for an arbitrary solution of the nonlinear equations-with the remainder term optimally controlled. These results give a complete generalization to the nonlinear setting of the large-scale regularity theory in homogenization for linear elliptic equations.

SUBMITTER: Armstrong S

PROVIDER: S-EPMC7217891 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Higher-Order Linearization and Regularity in Nonlinear Homogenization.

Armstrong Scott S Ferguson Samuel J SJ Kuusi Tuomo T

Archive for rational mechanics and analysis 20200409 2

We prove large-scale C ∞ regularity for solutions of nonlinear elliptic equations with random coefficients, thereby obtaining a version of the statement of Hilbert's 19th problem in the context of homogenization. The analysis proceeds by iteratively improving three statements together: (i) the regularity of the homogenized Lagrangian L ¯ , (ii) the commutation of higher-order linearization and homogenization, and (iii) large-scale C 0 , 1 -type regularity for higher-order linearization erro ...[more]

PMID: 32421078

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Project description:It is increasingly being recognized that physical interactions between distant chromosomal loci influence the expressivity of the genome. Thus, multiple enhancers may converge on a single gene promoter 1,2 and a single enhancer can stochastically loop to multiple promoters 3. Regulatory elements from neighboring domains or from other chromosomes may interact to generate chromatin structures poised for transcription4-8 or repression 9-11. However, a broader perspective on the formation and function of such networks remains largely unexplored. Using the high-resolution 4C (Circular Chromosome Conformation Capture) analysis, we identify here a genome-wide physical network between genomically imprinted domains impinging H19 imprinting control region (ICR). Sequences interacting with the H19 ICR constitutively map at or within most of known imprinted domains both in mouse embryonic stem cells and in vitro-derived embryoid bodies, despite distinct differences in chromatin environments. Moreover, all-to-all 3D DNA FISH analyses revealed that imprinted domains from 7 different chromosomes co-localize with each other in pair-wise patterns, highlighting the dynamic nature of these interactions. The observed interaction network is dependent on CTCF binding sites within the maternally inherited H19 ICR allele and delays reprogramming of epigenetic features at imprinted domains during male germline development. As other imprinted regions can interact with each other in an H19 ICR-dependent manner, the H19 ICR emerges as an organizer of chromosomal networks by specifically recognizing and reconfiguring imprinted domains. We propose that an ancient key regulatory region, such as the H19 ICR, gradually impacted epigenetic modifications via long-range interactions in the germline to facilitate the recruitment of imprinted genes and their formation in clusters during mammalian radiation. Furthermore, the perspective of epigenetic lesions de-stabilizing such chromosomal networks may advance our understanding of how quantitative traits influence human diseases, such as cancer.

Dataset Information

Higher-Order Linearization and Regularity in Nonlinear Homogenization.

Publications

Higher-Order Linearization and Regularity in Nonlinear Homogenization.

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