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Tumour-agnostic drugs in paediatric cancers.


ABSTRACT: The recognition that new cancer drugs can be truly tumour-agnostic based on mechanism-of-action is important for paediatric cancers, where access to novel targeted therapies developed for adult indications has sometimes been problematic. The recently approved drug larotrectinib is an excellent case study of the development of a tumour-agnostic drug relevant to children.

SUBMITTER: Chisholm JC 

PROVIDER: S-EPMC7217925 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Tumour-agnostic drugs in paediatric cancers.

Chisholm Julia C JC   Carceller Fernando F   Marshall Lynley V LV  

British journal of cancer 20200312 10


The recognition that new cancer drugs can be truly tumour-agnostic based on mechanism-of-action is important for paediatric cancers, where access to novel targeted therapies developed for adult indications has sometimes been problematic. The recently approved drug larotrectinib is an excellent case study of the development of a tumour-agnostic drug relevant to children. ...[more]

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