ComW?6 Stimulates Transcription of Pneumococcal Competence Genes in vitro.
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ABSTRACT:
SUBMITTER: Inniss NL
PROVIDER: S-EPMC7218084 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
ComWΔ6 Stimulates Transcription of Pneumococcal Competence Genes <i>in vitro</i>.
Inniss Nicole L NL Morrison Donald A DA
Frontiers in molecular biosciences 20200506
The alternative streptococcal σ-factor and master competence regulator, σ<sup>X</sup>, stimulates transcription from competence promoters, <i>in vitro.</i> As the only known alternative σ-factor in streptococci, σ<sup>X</sup> expression is tightly controlled in each species and has a specific physiological role. Pneumococcal transformation also requires the DNA binding activity of ComW, a known σ<sup>X</sup> activator and stabilizer. Mutations to the housekeeping σ factor, σ<sup>A</sup>, partial ...[more]
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