Dataset Information

Over the Horizon: The Present and Future of Endovascular Neural Recording and Stimulation.

ABSTRACT: The past decade has witnessed an explosion in applications for neural recording and stimulation in the treatment of clinical disorders. Neuromodulatory approaches are now a mainstay of care for essential tremor and Parkinson's disease, and are expanding rapidly into a wide range of other neurological and psychiatric diseases. In parallel, advancements in endovascular approaches to cerebrovascular diseases have resulted in minimally invasive techniques that deliver devices to neural tissue in the central and peripheral nervous systems, with significantly improved safety and efficacy. In this review, we discuss the history of endovascular neural recording and stimulation, its current progress, and applications for neurological disease.

SUBMITTER: Fan JZ

PROVIDER: S-EPMC7218134 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Over the Horizon: The Present and Future of Endovascular Neural Recording and Stimulation.

Fan James Z JZ Lopez-Rivera Victor V Sheth Sunil A SA

Frontiers in neuroscience 20200506

The past decade has witnessed an explosion in applications for neural recording and stimulation in the treatment of clinical disorders. Neuromodulatory approaches are now a mainstay of care for essential tremor and Parkinson's disease, and are expanding rapidly into a wide range of other neurological and psychiatric diseases. In parallel, advancements in endovascular approaches to cerebrovascular diseases have resulted in minimally invasive techniques that deliver devices to neural tissue in the ...[more]

PMID: 32435184

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Project description:Objective.Neuromodulation of visceral nerves is being intensively studied for treating a wide range of conditions, but effective translation requires increasing the efficacy and predictability of neural interface performance. Here we use computational models of rat visceral nerve to predict how neuroanatomical variability could affect both electrical stimulation and recording with an experimental planar neural interface.Approach.We developed a hybrid computational pipeline,VisceralNerveEnsembleRecording andStimulation (ViNERS), to couple finite-element modelling of extracellular electrical fields with biophysical simulations of individual axons. Anatomical properties of fascicles and axons in rat pelvic and vagus nerves were measured or obtained from public datasets. To validate ViNERS, we simulated pelvic nerve stimulation and recording with an experimental four-electrode planar array.Main results.Axon diameters measured from pelvic nerve were used to model a population of myelinated and unmyelinated axons and simulate recordings of electrically evoked single-unit field potentials (SUFPs). Across visceral nerve fascicles of increasing size, our simulations predicted an increase in stimulation threshold and a decrease in SUFP amplitude. Simulated threshold changes were dominated by changes in perineurium thickness, which correlates with fascicle diameter. We also demonstrated that ViNERS could simulate recordings of electrically-evoked compound action potentials (ECAPs) that were qualitatively similar to pelvic nerve recording made with the array used for simulation.Significance.We introduce ViNERS as a new open-source computational tool for modelling large-scale stimulation and recording from visceral nerves. ViNERS predicts how neuroanatomical variation in rat pelvic nerve affects stimulation and recording with an experimental planar electrode array. We show ViNERS can simulate ECAPS that capture features of our recordings, but our results suggest the underlying NEURON models need to be further refined and specifically adapted to accurately simulate visceral nerve axons.

Project description:In vivo multi-electrode arrays (MEAs) can sense electrical signals from a small set of neurons or modulate neural activity through micro-stimulation. Electrode's geometric surface area (GSA) and impedance are important for both unit recording and neural stimulation. Smaller GSA is preferred due to enhanced selectivity of neural signal, but it tends to increase electrode impedance. Higher impedance leads to increased electrical noise and signal loss in single unit neural recording. It also yields a smaller charge injection window for safe neural stimulation. To address these issues, poly (3, 4-ethylenedioxythiophene) - ionic liquid (PEDOT-IL) conducting polymers were electrochemically polymerized on the surface of the microelectrodes. The PEDOT-IL coating reduced the electrode impedance modulus by over 35 times at 1 kHz. It also exhibited compelling nanostructure in surface morphology and significant impedance reduction in other physiologically relevant range (100Hz-1000Hz). PEDOT-IL coated electrodes exhibited a Charge Storage Capacity (CSC) that was about 20 times larger than that of bare electrodes. The neural recording performance of PEDOT-IL coated electrodes was also compared with uncoated electrodes and PEDOT-poly (styrenesulfonate) (PSS) coated electrodes in rat barrel cortex (SI). Spontaneous neural activity and sensory evoked neural response were utilized for characterizing the electrode performance. The PEDOT-IL electrodes exhibited a higher unit yield and signal-to-noise ratio (SNR) in vivo. The local field potential recording was benefited from the low impedance PEDOT-IL coating in noise and artifact reduction as well. Moreover, cell culture on PEDOT-IL coating demonstrated that the material is safe for neural tissue and reduces astrocyte fouling. Taken together, PEDOT-IL coating has the potential to benefit neural recording and stimulation electrodes, especially when integrated with novel small GSA electrode arrays designed for high recording density, minimal insertion damage and alleviated tissue reaction.

Dataset Information

Over the Horizon: The Present and Future of Endovascular Neural Recording and Stimulation.

Publications

Over the Horizon: The Present and Future of Endovascular Neural Recording and Stimulation.

Similar Datasets

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