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Nitrous oxide/oxygen plus acetaminophen versus morphine in ST elevation myocardial infarction: open-label, cluster-randomized, non-inferiority study.


ABSTRACT: BACKGROUND:Studies have shown disparate results on the consequences of morphine use in ST-segment elevation myocardial infarction (STEMI). No study has evaluated alternative treatments that could be at least non-inferior to morphine without its potentially damaging consequences for myocardial function and platelet reactivity. The aim of this study was to evaluate whether nitrous oxide/oxygen plus intravenous acetaminophen (NOO-A) is non-inferior to morphine to control chest pain in STEMI patients. METHODS:This multicenter, open-label, cluster-randomized, controlled, non-inferiority study compared NOO-A with morphine in 684 prehospital patients with ongoing suspected STEMI of

SUBMITTER: Charpentier S 

PROVIDER: S-EPMC7218609 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Nitrous oxide/oxygen plus acetaminophen versus morphine in ST elevation myocardial infarction: open-label, cluster-randomized, non-inferiority study.

Charpentier Sandrine S   Galinski Michel M   Bounes Vincent V   Ricard-Hibon Agnès A   El-Khoury Carlos C   Elbaz Meyer M   Ageron François-Xavier FX   Manzo-Silberman Stéphane S   Soulat Louis L   Lapostolle Frédéric F   Gérard Alexandre A   Bregeaud Delphine D   Bongard Vanina V   Bonnefoy-Cudraz Eric E  

Scandinavian journal of trauma, resuscitation and emergency medicine 20200512 1


<h4>Background</h4>Studies have shown disparate results on the consequences of morphine use in ST-segment elevation myocardial infarction (STEMI). No study has evaluated alternative treatments that could be at least non-inferior to morphine without its potentially damaging consequences for myocardial function and platelet reactivity. The aim of this study was to evaluate whether nitrous oxide/oxygen plus intravenous acetaminophen (NOO-A) is non-inferior to morphine to control chest pain in STEMI  ...[more]

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2020-05-27 | GSE103182 | GEO