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Genetic risk scores based on risk-associated single nucleotide polymorphisms can reveal inherited risk of bladder cancer in Chinese population.

ABSTRACT: Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with bladder cancer (BCa) risk in Caucasian and East Asian population. The objective of this study was to validate these SNPs in Chinese population and evaluate whether these SNPs could differentiate the individual inherited risk for BCa.A case-control study including 581 BCa cases and 1561 healthy controls was performed. Germline DNA samples from all individuals were genotyped for eight SNPs. Genetic risk score (GRS) was calculated for each individual based on the odds ratios and risk allele frequencies of five risk-associated SNPs.Among eight SNPs evaluated in this study, rs798766 at 4p16.3 [OR?=?1.39 (1.15-1.67), P?1.2) groups, the likelihoods of BCa were 25.2%, 33.7% and 55.0%, respectively (P-trend?

SUBMITTER: Xu C 

PROVIDER: S-EPMC7220229 | biostudies-literature | 2020 May

REPOSITORIES: biostudies-literature

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Genetic risk scores based on risk-associated single nucleotide polymorphisms can reveal inherited risk of bladder cancer in Chinese population.

Xu Chenyang C   Lin Xiaoling X   Qian Wei W   Na Rong R   Yu Hongjie H   Jia Haifei H   Jiang Haowen H   Fang Zujun Z   Zheng S Lilly SL   Ding Qiang Q   Wu Yishuo Y   Zheng Jie J   Xu Jianfeng J  

Medicine 20200501 19

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with bladder cancer (BCa) risk in Caucasian and East Asian population. The objective of this study was to validate these SNPs in Chinese population and evaluate whether these SNPs could differentiate the individual inherited risk for BCa.A case-control study including 581 BCa cases and 1561 healthy controls was performed. Germline DNA samples from all individuals were genotyped for eight SNPs. Genet  ...[more]

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