Rs10757274 gene polymorphisms in coronary artery disease: A systematic review and a meta-analysis.

ABSTRACT: BACKGROUND:It has been reported the rs10757274 SNP (present on locus 9p21 in the gene for CDKN2BAS1) might be associated with susceptibility to coronary artery disease (CAD). Owing to mixed and inconclusive results, we conducted a meta-analysis to investigate the association between rs10757274 polymorphism and the risk of CAD. OBJECTIVES:The present study aimed to investigate the relationship between rs10757274 polymorphism and the risk of CAD. METHODS:All studies of the rs10757274 SNP with CAD that were published between 2007 and 2018 were retrieved from the PubMed database. Meta-analysis was performed with Stata 14.0 software. The effect size of the rs10757274 SNP with CAD risk was assessed based on the odds ratios (ORs) with calculation of 95% confidence interval (CI). RESULTS:Eleven studies including 52,209 subjects (cases: 7990, controls: 44,219) were included in the final data combination. Pooled overall analyses showed that rs10757274 (allele model: P?

SUBMITTER: Xu LB 

PROVIDER: S-EPMC7220330 | biostudies-literature | 2020 Jan

REPOSITORIES: biostudies-literature