Ontology highlight
ABSTRACT:
SUBMITTER: Bourdenx M
PROVIDER: S-EPMC7220339 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Bourdenx M M Nioche A A Dovero S S Arotcarena M-L ML Camus S S Porras G G Thiolat M-L ML Rougier N P NP Prigent A A Aubert P P Bohic S S Sandt C C Laferrière F F Doudnikoff E E Kruse N N Mollenhauer B B Novello S S Morari M M Leste-Lasserre T T Damas I Trigo IT Goillandeau M M Perier C C Estrada C C Garcia-Carrillo N N Recasens A A Vaikath N N NN El-Agnaf O M A OMA Herrero M T MT Derkinderen P P Vila M M Obeso J A JA Dehay B B Bezard E E
Science advances 20200513 20
Dopaminergic neuronal cell death, associated with intracellular α-synuclein (α-syn)-rich protein aggregates [termed "Lewy bodies" (LBs)], is a well-established characteristic of Parkinson's disease (PD). Much evidence, accumulated from multiple experimental models, has suggested that α-syn plays a role in PD pathogenesis, not only as a trigger of pathology but also as a mediator of disease progression through pathological spreading. Here, we have used a machine learning-based approach to identif ...[more]