Case report: simultaneous occurrence of multiple myeloma and non-Hodgkin lymphoma treated by CAR T therapy.

ABSTRACT: RATIONALE:B cell lymphoma can co-occur with multiple myeloma (MM), and the prognosis in this case is usually poor. We propose the combination of CD19-chimeric antigen receptor (CAR) T cells and BCMA-CAR T cells for the treatment of such patients to obtain a superior prognosis. PATIENT CONCERNS:We present a 50-year-old patient with previous B cell lymphoma and subsequent multiple myeloma (MM). DIAGNOSIS:A diagnosis of B cell lymphoma and MM was made. INTERVENTIONS:The patient was treated with a combination of haploidentical CD19-chimeric antigen receptor (CAR) T cells and BCMA-CAR T cells. OUTCOMES:After CAR T cell therapy, the monoclonal plasma cells in the bone marrow and M protein disappeared. LESSONS:The combination therapy of CD19- and BCMA-CAR T cells is an effective measure to treat patients with concomitant or borderline cases of B cell lymphoma and MM.

SUBMITTER: Li T 

PROVIDER: S-EPMC7220358 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature