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The effect of periodontal bacteria infection on incidence and prognosis of cancer: A systematic review and meta-analysis.

ABSTRACT: BACKGROUND:Periodontal bacteria is the major pathogens in the oral cavity and the main cause of adult chronic periodontitis, but their association with incidence and prognosis in cancer is controversial. The aim of this study was to evaluate the effect of periodontal bacteria infection on incidence and prognosis of cancer. METHODS:A systematic literature search of PubMed, Embase, Web of Science, and Cochrane Library databases was performed to obtain 39 studies comprising 7184 participants. The incidence of cancer was evaluated as odd ratios (OR) with a 95% confidence interval (95% CI) using Review Manager 5.2 software. Overall survival, cancer-specific survival and disease-free survival, which were measured as hazard ratios (HR) with a 95% CI using Review Manager 5.2 software. RESULTS:Our results indicated that periodontal bacteria infection increased the incidence of cancer (OR?=?1.25; 95%CI: 1.03-1.52) and was associated with poor overall survival (HR?=?1.75; 95% CI: 1.40-2.20), disease-free survival (HR?=?2.18; 95%CI: 1.24-3.84) and cancer-specific survival (HR?=?1.85, 95%CI: 1.44-2.39). Subgroup analysis indicted that the risk of cancer was associated with Porphyromonas gingivalis (Pg) infection (OR?=?2.16; 95%CI: 1.34-3.47) and Prevotella intermedia (Pi) infection (OR?=?1.28; 95%CI: 1.01-1.63) but not Tannerella forsythia (Tf) (OR?=?1.06; 95%CI: 0.8-1.41), Treponema denticola (Td) (OR?=?1.30; 95%CI: 0.99-1.72), Aggregatibacter actinomycetemcomitans (Aa) (OR?=?1.00; 95%CI: 0.48-2.08) and Fusobacterium nucleatum (Fn) (OR?=?0.61; 95%CI: 0.32-1.16). CONCLUSION:This meta-analysis revealed periodontal bacteria infection increased the incidence of cancer and predicted poor prognosis of cancer.

SUBMITTER: Xiao L

PROVIDER: S-EPMC7220362 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature

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The effect of periodontal bacteria infection on incidence and prognosis of cancer: A systematic review and meta-analysis.

Xiao Li L Zhang Qianyu Q Peng Yanshuang Y Wang Daqing D Liu Ying Y

Medicine 20200401 15

<h4>Background</h4>Periodontal bacteria is the major pathogens in the oral cavity and the main cause of adult chronic periodontitis, but their association with incidence and prognosis in cancer is controversial. The aim of this study was to evaluate the effect of periodontal bacteria infection on incidence and prognosis of cancer.<h4>Methods</h4>A systematic literature search of PubMed, Embase, Web of Science, and Cochrane Library databases was performed to obtain 39 studies comprising 7184 part ...[more]

PMID: 32282725

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Project description:Metformin has been suggested to reduce thyroid cancer incidence and to improve thyroid cancer prognosis. We aimed to evaluate the associations between metformin and thyroid cancer incidence and prognosis (metastasis/recurrence/progression-free survival). Cochrane Library, PubMed, ClinicalTrials.gov, and U.S. National Library of Medicine Clinical Trials were searched through the end of December 2021. Data were collected from original observational studies or clinical trials on the incidence or prognosis of thyroid carcinoma outcomes in type 2 diabetes mellitus (T2DM) patients with and without metformin use. Risk of bias in non-randomized studies of interventions (ROBINS-I) tool and Grading of Recommendations, and Assessment, Development and Evaluations (GRADE) approach were used to evaluate the risk of bias and quality of the body of evidence, respectively. In general, 4 studies were related to the thyroid cancer incidence, including 1,705,123 participants metformin users and non-users and yielding a total of 3,238 thyroid cancer events; 3 studies reported the prognosis of thyroid carcinoma based on a total of 4,972 individuals with primary thyroid carcinoma and comorbid type 2 diabetes, and the number of thyroid cancer prognosis cases ranged from 3 to 79. The overall risk of bias of the included studies ranged from moderate to serious. In the random-effects model, the summary relative risk (SRR) for thyroid cancer incidence was 0.743 (95% CI: 0.453-1.220; I2 = 88.7%, low certainty) comparing metformin users to non-users; and SRR for the prognosis of thyroid cancer was 0.504 (95% CI: 0.178-1.430; I2 = 57.5%, low certainty). Non-statistically significant negative associations between metformin use and incidence and prognosis of thyroid cancer were found in the current analysis, although the quantity and quality of the evidence were limited. Futher investigation is needed to evaluate the clinical benefits of metformin on thyroid cancer prevention and treatments.

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The effect of periodontal bacteria infection on incidence and prognosis of cancer: A systematic review and meta-analysis.

Publications

The effect of periodontal bacteria infection on incidence and prognosis of cancer: A systematic review and meta-analysis.

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