Expression of SREBP2 and cholesterol metabolism related genes in TCGA glioma cohorts.
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ABSTRACT:
SUBMITTER: Li D
PROVIDER: S-EPMC7220679 | biostudies-literature | 2020 Mar
REPOSITORIES: biostudies-literature
Publications
Expression of SREBP2 and cholesterol metabolism related genes in TCGA glioma cohorts.
Li Dali D Li Shenglan S Xue Allen Z AZ Smith Callahan Laura A LA Liu Ying Y
Medicine 20200301 12
Diffuse gliomas are the most common primary brain tumors. The Cancer Genome Atlas (TCGA) database provides correlative evidence between altered molecular pathways and gliomas. Dysregulated cholesterol homeostasis emerges as a potential indicator of the pathogenesis of gliomas.Mining large cohorts from the TCGA together with database from the Chinese Glioma Genome Atlas (CGGA) for confirmation, we compared gene expression of cholesterol synthesis master regulator SREBP2 and its regulatory network ...[more]
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