Ontology highlight
ABSTRACT:
SUBMITTER: Tan JHL
PROVIDER: S-EPMC7220855 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Tan Joel H L JHL Wollmann Heike H van Pelt Ans M M AMM Kaldis Philipp P Messerschmidt Daniel M DM
Stem cell reports 20200416 5
Spermatogenesis relies on exquisite stem cell homeostasis, the carefully balanced self-renewal and differentiation of spermatogonial stem cells (SSCs). Disturbing this equilibrium will likely manifest through sub- or infertility, a global health issue with often idiopathic presentation. In this respect, disease phenotypes caused by haploinsufficiency of otherwise vital developmental genes are of particular interest. Here, we show that mice heterozygous for Trim28, an essential epigenetic regulat ...[more]