Ontology highlight
ABSTRACT:
SUBMITTER: Souza C
PROVIDER: S-EPMC7220917 | biostudies-literature | 2020 May
REPOSITORIES: biostudies-literature
Souza Cláudia C Sanches Rodrigo C O RCO Assis Natan R G NRG Marinho Fábio V FV Mambelli Fábio S FS Morais Suellen B SB Gimenez Enrico G T EGT Guimarães Erika S ES Castro Tiago B R TBR Oliveira Sergio C SC
Scientific reports 20200513 1
Schistosomiasis is a human parasitic disease responsible for serious consequences for public health, as well as severe socioeconomic impacts in developing countries. Here, we provide evidence that the adaptor molecule STING plays an important role in Schistosoma mansoni infection. S. mansoni DNA is sensed by cGAS leading to STING activation in murine embryonic fibroblasts (MEFs). Sting<sup>-/-</sup> and C57BL/6 (WT) mice were infected with schistosome cercariae in order to assess parasite burden ...[more]