Elevated microRNA-125b inhibits cytotrophoblast invasion and impairs endothelial cell function in preeclampsia.
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ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC7220944 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Elevated microRNA-125b inhibits cytotrophoblast invasion and impairs endothelial cell function in preeclampsia.
Li Qinghua Q Han Yangyang Y Xu Peng P Yin Lingxuan L Si Yanru Y Zhang Cuijuan C Meng Yuhan Y Feng Weiguo W Pan Zhifang Z Gao Zhiqin Z Li Jie J Yang Weiwei W
Cell death discovery 20200513
Preeclampsia (PE) is a life-threatening disorder of human pregnancy affecting 5-8% of all pregnancies. Currently, PE remains an elusive complicated and heterogenous medical condition with no early marker or symptoms is recognized for this serious pregnancy complications. Here, we profiled the plasma miRNA expression patterns associated with preeclampsia and found 16 miRNAs were deregulated (<i>p</i> < 0.01) in patients who later developed PE. Circulating hsa-miR-125b was aberrantly upregulated i ...[more]
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