Ontology highlight
ABSTRACT:
SUBMITTER: Dimopoulos G
PROVIDER: S-EPMC7221383 | biostudies-literature | 2020 Jul
REPOSITORIES: biostudies-literature
Dimopoulos George G de Mast Quirijn Q Markou Nikolaos N Theodorakopoulou Maria M Komnos Apostolos A Mouktaroudi Maria M Netea Mihai G MG Spyridopoulos Themistoklis T Verheggen Rebecca J RJ Hoogerwerf Jacobien J Lachana Alexandra A van de Veerdonk Frank L FL Giamarellos-Bourboulis Evangelos J EJ
Cell host & microbe 20200514 1
Dysregulation of inflammation is hypothesized to play a crucial role in the severe complications of COVID-19, with the IL-1/IL-6 pathway being central. Here, we report on the treatment of eight severe COVID-19 pneumonia patients-seven hospitalized in intensive care units (ICUs) in Greece and one non-ICU patient in the Netherlands-with the interleukin-1 receptor antagonist Anakinra. All patients scored positive for the hemophagocytosis score (HScore) and were diagnosed with secondary hemophagocyt ...[more]