Emerging Nano- and Micro-Technologies Used in the Treatment of Type-1 Diabetes.

ABSTRACT: Type-1 diabetes is characterized by high blood glucose levels due to a failure of insulin secretion from beta cells within pancreatic islets. Current treatment strategies consist of multiple, daily injections of insulin or transplantation of either the whole pancreas or isolated pancreatic islets. While there are different forms of insulin with tunable pharmacokinetics (fast, intermediate, and long-acting), improper dosing continues to be a major limitation often leading to complications resulting from hyper- or hypo-glycemia. Glucose-responsive insulin delivery systems, consisting of a glucose sensor connected to an insulin infusion pump, have improved dosing but they still suffer from inaccurate feedback, biofouling and poor patient compliance. Islet transplantation is a promising strate

SUBMITTER: Primavera R 

PROVIDER: S-EPMC7221526 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature