Ontology highlight
ABSTRACT:
SUBMITTER: Hintzen JCJ
PROVIDER: S-EPMC7221964 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Hintzen Jordi C J JCJ Poater Jordi J Kumar Kiran K Al Temimi Abbas H K AHK Pieters Bas J G E BJGE Paton Robert S RS Bickelhaupt F Matthias FM Mecinović Jasmin J
Molecules (Basel, Switzerland) 20200421 8
Gaining a fundamental insight into the biomolecular recognition of posttranslationally modified histones by epigenetic reader proteins is of crucial importance to understanding the regulation of the activity of human genes. Here, we seek to establish whether trimethylthialysine, a simple trimethyllysine analogue generated through cysteine alkylation, is a good trimethyllysine mimic for studies on molecular recognition by reader proteins. Histone peptides bearing trimethylthialysine and trimethyl ...[more]