Ontology highlight
ABSTRACT:
SUBMITTER: Bridoux J
PROVIDER: S-EPMC7221983 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Bridoux Jessica J Neyt Sara S Debie Pieterjan P Descamps Benedicte B Devoogdt Nick N Cleeren Frederik F Bormans Guy G Broisat Alexis A Caveliers Vicky V Xavier Catarina C Vanhove Christian C Hernot Sophie S
Molecules (Basel, Switzerland) 20200416 8
Since atherosclerotic plaques are small and sparse, their non-invasive detection via PET imaging requires both highly specific radiotracers as well as imaging systems with high sensitivity and resolution. This study aimed to assess the targeting and biodistribution of a novel fluorine-18 anti-VCAM-1 Nanobody (Nb), and to investigate whether sub-millimetre resolution PET imaging could improve detectability of plaques in mice. The anti-VCAM-1 Nb functionalised with the novel restrained complexing ...[more]